Antimicrobial activity of Vitamin-D in human macrophages isolated from older adult women peripheral blood

Vitamin D deficiency is becoming a public health concern all over the world including India and its deficiency is associated with several adverse health outcomes. Many studies suggest that among all age groups geriatric population are more susceptible to Vitamin D deficiency and also more prone against infections than other age groups. A vitamin D replete state appears to benefit most infections. In present study the association of vitamin D status with antimicrobial activity of cultured macrophages isolated within an exclusively rural elderly women population cohort were assessed, since they are at an increased risk of both insufficient and deficient vitamin D status. We found that in vitro supplementation of vitamin D increases antimicrobial activity in monocytes derived macrophages (MDM), which also influences their current Vitamin D status.